Wisdom is the last dumping ground for stats, for being like charisma and intelligence it has no direct influence on combat. I considered long and hard on how to have this affect the players, and settled on the idea that the character would have made friends or enemies during their early life; the wisdom table is meant to reflect that.
Now, most times, a character couldn’t give a rat’s ass what their family thought of them growing up. Family members do not generally have any place in D&D (nerds must dislike them, hm?), and I haven’t seen a player make much use of the positive results of this table. Most of the time, a player is too busy globetrotting to care much what mum and dad are doing back on the farm. Still, I feel the table has relevance and I don’t feel any need to change the subject matter.
The biggest dispute might be the result where a proficiency or a number of cantrips are lost. I agree, this is nasty. So is losing a limb, or being covered with burn scars. If you accept the negative results of the first two tables, you must accept that occasionally a character is going to have fucked up their studies in their youth. You might want to create some means by which they can take “night courses” and get back that proficiency or cantrip. Or simply eliminate the result from your campaign.
One thing that can be considered is the juxtaposition of this table with the father's profession table I posted days ago. If your father is no one special, then it doesn't much matter how the character is viewed. But if your father was merchant guildmaster (and loaded), and your fighter is HATED by his family...well, that just sucks, doesn't it?